Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp
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چکیده
منابع مشابه
Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.
Antibiotics have either bactericidal or bacteriostatic activity. However, they also induce considerable gene expression in bacteria when used at subinhibitory concentrations (below the MIC). We found that lincomycin, which inhibits protein synthesis by binding to the ribosomes of Gram-positive bacteria, was effective for inducing the expression of genes involved in secondary metabolism in Strep...
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The addition of extracellular ATP (exATP) to four Streptomyces strains had similar effects: low exATP levels stimulated antibiotic production and high levels reduced it. Compared with antibiotic production, the concentrations of intracellular ATP (inATP) in the tested strains were opposite, which suggests a role of inATP in regulating secondary metabolite production. Under inactivation of the p...
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Streptomyces is an extremely important bacterium for industry, since approximately two thirds of all antibiotics are synthesized by members of this genus. Furthermore, Streptomycetes produce large numbers of eukaryotic cell differentiation and apoptosis inducers. Streptomyces is a mycelial soil bacterium characterized by a complex developmental cycle that includes programmed cell death (PCD) ph...
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In the course of our antibiotic screening program several lincomycin-producing Streptomyces espinosus strains were isolated. These strains show a remarkable temperature dependence regarding the production of lincomycin. At incubation temperatures up to 28°C little or no lincomycin is produced despite good mycelial growth. Incubation above 28°C results in an up to hundred-fold increase of antibi...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 2015
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.04214-14